The number of drug-related risk factors in the etiological analysis of ARP in this study was higher than that in other studies (15, 16), probably because SCMC is one of the largest cancer centers in China, with many hematopathy patients receiving treatment at the center, and because asparaginase is a commonly used chemotherapy drug for acute lymphoblastic leukemia, thus increasing the proportion of cases with drug-induced ARP. This evidence concerns the gene ASPG and acute lymphoblastic leukemia.