LDLR and hereditary spastic paraplegia: Congenital metabolic diseases included two cases of familial hypercholesterolemia (FH) caused by an LDLR gene mutation and one case of hypertriglyceridemia caused by an APOB gene mutation; systemic diseases included three cases of Henoch–Schonlein purpura (HSP), two cases of systemic lupus erythematosus (SLE), one case of autoimmune pancreatitis (AIP) with ARP, and one case AIP with CP.