The findings reported by the INSPPIRE were that at least one pancreatitis-related gene mutation was found in 48 and 73% of ARP and CP patients, respectively, and SPINK1 and PRSS1 mutations were more closely related to CP, and children with ARP with pathogenic PRSS1 variants rapidly progress to CP (1, 10). The gene discussed is SPINK1; the disease is pancreatitis.