Congenital metabolic diseases included two cases of familial hypercholesterolemia (FH) caused by an LDLR gene mutation and one case of hypertriglyceridemia caused by an APOB gene mutation; systemic diseases included three cases of Henoch–Schonlein purpura (HSP), two cases of systemic lupus erythematosus (SLE), one case of autoimmune pancreatitis (AIP) with ARP, and one case AIP with CP. This evidence concerns the gene APOB and hereditary spastic paraplegia.