In T2D patients, Bruehl et al. [99] measured an increased responsiveness to CRH, coupled with diminished suppression after dexamethasone-responsive test, indicating an abnormality in HPA feedback sensitivity (suspected to be a predictive factor of T2D, [123]), and related to decreased cognitive performance [124], but the brain pathways that mediate these links have not been understood yet. Here, CRH is linked to type 2 diabetes mellitus.