Moreover, this approach has also been used in pig model of autosomal dominant Retinitis Pigmentosa (adRP) for the correction of P23H mutation in the rhodopsin (RHO) gene (Jalligampala et al., 2021) and in non-human primates for the modification of the proprotein convertase subtilisin/kexin type 9 (PCSK9) gene responsible for hypercholesterolemia (Wang et al., 2018a; Wang et al., 2021). This evidence concerns the gene RHO and familial hypercholesterolemia.