PHOSPHO1 and type 2 diabetes mellitus: A panel of PHOSPHO1 inhibitors was screened from chemical libraries (Roberts et al., 2007; Kiffer-Moreira et al., 2013; Bravo et al., 2014), among which several proton pump inhibitors were reported to enhance the effect of antidiabetic medications in animal models or T2D patients (Mefford and Wade, 2009; Hove et al., 2010; Swamy et al., 2010; Boj-Carceller et al., 2011; Barchetta et al., 2015; Bozkuş et al., 2020; Gamil et al., 2020).