Epigenomic association studies indicated that the methylation levels of PHOSPHO1 in whole blood of subjects were positively correlated with their HDL cholesterol levels (Dayeh et al., 2016; Sayols-Baixeras et al., 2016) and negatively correlated with the future risk of developing type II diabetes (T2D) (Chambers et al., 2015). The gene discussed is PHOSPHO1; the disease is type 2 diabetes mellitus.