Several SNP sites have been found to be associated with the risk of OM development, such as rs16944, rs2234663, rs1143627, rs4251961, and rs1800796 (interleukin, IL genes) (Alves De Souza et al., 2017; Jiang et al., 2020b), rs45567233 (cathepsin G, CTSG gene) (Pérez-Is et al., 2019), rs1799750, and rs1144393 (matrix metalloproteinase-1, MMP-1 gene) (Kong et al., 2017), implying SNPs participate in OM pathogenesis. The gene discussed is CTSG; the disease is ocular melanoma.