In LUAD, WNT2, WNT9B, and WNT10A represented a significantly positive correlation with six immune cells, including B cell, CD4+ T cell, CD8+ T cell, dendritic cell, macrophage, and neutrophil; WNT3 and WNT8B were positively correlated with tumor purity, while WNT1/2/2B/6/7A/7B/9A/9B/10A/10B/16 were negatively correlated with tumor purity. The gene discussed is WNT8B; the disease is neoplasm.