WNT8B is one of the typical WNT ligands, transcriptionally regulated by zinc finger transcription factor 191 (ZNF 191) and playing an important role in hepatocellular carcinoma (HCC) proliferation through the canonical WNT pathway (serving as a new prognostic marker for HCC) (51). The gene discussed is WNT8B; the disease is hepatocellular carcinoma.