With the LUAD development, the WNT2 expression decreases as a whole, reaching the lowest level when the tumor progresses to stage IV; the expression of WNT2B presents no obvious change but tends to decrease with the disease progression, of which a few patients show a sudden rise in the expression in stage IV; WNT11 showed an increase in the expression with the tumor development. Here, WNT2 is linked to neoplasm.