We found that metastatic dysregulation of LDLR, CD36, FABP4, SCD, FASN, LPL, and APOA1 shows concordance with CRC cell tropism toward the liver versus lung, whereas LDLR, CD36, FABP4, SCD, AGPAT1, and FASN alterations are associated with CRC patients’ prognosis. This evidence concerns the gene APOA1 and colorectal carcinoma.