We found that metastatic dysregulation of LDLR, CD36, FABP4, SCD, FASN, LPL, and APOA1 shows concordance with CRC cell tropism toward the liver versus lung, whereas LDLR, CD36, FABP4, SCD, AGPAT1, and FASN alterations are associated with CRC patients’ prognosis. Here, LDLR is linked to colorectal carcinoma.