Furthermore, PTPN4 and PTPN13 are favorable prognostic biomarkers for breast cancer patients (35, 36), in which PTPN13 induces apoptosis of breast cancer cells and inhibits breast tumor aggressiveness by directly inactivating Src kinase and stabilizing intercellular adhesion and promoting desmosome formation (37–39). This evidence concerns the gene PTPN4 and breast carcinoma.