Mechanistically, silencing of PTPN18 induced ferroptosis in endometrial cancer cells by increasing intracellular reactive oxygen species (ROS) levels and p-p38 expression as well as decreasing the expression of glutathione peroxidase 4 (GPX4) and system xc(-) cystine/glutamate antiporter (xCT) (72). This evidence concerns the gene PTPN18 and endometrial cancer.