Furthermore, inhibition of PTPN3 in lymphocytes expands the proportion of tumor-infiltrating lymphocytes and activated lymphocyte cytotoxicity, as well as the anticancer effect on small cell lung cancer (SCLC) and large cell neuroendocrine carcinoma (LCNEC) (200, 201). This evidence concerns the gene PTPN3 and large cell neuroendocrine carcinoma.