Furthermore, deletion of PTPN1 and PTPN2 in DCs stimulated the growth of IL-12 and IFN-γ, which amplified the IL-12/STAT4/IFN-γ/STAT1/IL-12 positive autocrine loop, boosting the therapeutic potential of mature monocyte-derived dendritic cells (moDCs) in tumor-bearing mice (193). The gene discussed is PTPN1; the disease is neoplasm.