When combined EGFR and CD4 expression was analyzed, it was found that EGFR+/CD4+ expression was associated with never smokers (p=0.03), tongue tumor disease site (p=0.03), T1 tumors (p=0.02), N0 tumors (p=0.002), no LVI (p=0.02) and no BI (p=0.01) (Table 4). Here, CD4 is linked to tongue neoplasm.