SMAD5 and cutaneous melanoma: characterized the regulatory networks of lncRNAs and mRNAs in cutaneous melanoma (SKCM) by analyzing expression profile data and identified potential therapeutic targets (35) A study by Ying-Juan Zheng found that SMAD5-AS1 knockdown inhibited EMT, cell proliferation, migration, and invasion in NPC by upregulating miR-106a-5p and downregulating SMAD5 (21).