The top two most abundant signaling pathways or biological processes were listed according to the scores.GSEA confirmed that BTK and CD72 were mainly enriched in the IGA-producing intestinal immune network, B-cell receptor signaling pathway; PTPN6 and VAV1 were mainly associated with primary immunodeficiency, the IGA-producing intestinal immune network (Figure 5). Here, PTPN6 is linked to inborn error of immunity.