SEMA3D and pancreatic ductal adenocarcinoma: Whatever the case, Sema3d and PlxnD1 have been shown to promote metastasis in various types of cancer and regulate the EMT of pancreatic ductal adenocarcinoma (43), which reveals that the complex function of Sema3d, and perhaps play the opposite role in a variety of cancers or cells through different receptors or signaling pathways.