Therefore, we examined EMT markers E-cadherin and vimentin in Sema3d low- and high-expressed HCC tissue by IHC (Figure 6B), and the Spearman’s rank correlation found that Sema3d expression level positively correlates with E-cadherin and negatively related with Vimentin (Supplementary Figure S8). This evidence concerns the gene CDH1 and hepatocellular carcinoma.