RET and non-small cell lung carcinoma: However, while clinical assessment determined that alectinib was well-tolerated in treatment-naïve patients, twice-daily oral administration of alectinib (600mg) exerts minimal activity in RET fusion-positive NSCLC patients (133) and yielded an overall response rate (ORR) of 4% (1/25 patients) and PFS of 3.4 months (135).