ALK and non-small cell lung carcinoma: Alectinib received accelerated FDA approval in 2015 for treatment of patients with ALK fusion-positive metastatic NSCLC that were unresponsive to crizotinib, an ALK and ROS1 inhibitor (253), and is currently in clinical trials to test efficacy against other solid tumors alone (NCT04116541, NCT02314481, NCT03194893) or in combination with other compounds (NCT03944772).