However, a phase I/Ib trial (NCT01877811) revealed that daily oral administration of agerafenib (275mg) does not elicit response in RET fusion-positive NSCLC patients (0/20) and conferred multiple treatment-related adverse events such as diarrhea, fatigue, and hypophosphatemia (263). The gene discussed is RET; the disease is non-small cell lung carcinoma.