FLT1 and breast cancer: Lenvatinib (E7080; Lenvima ®) is an oral ATP-competitive MKI with activity against FLT-1, FLT-4, KIT, FGFR1, PDGFR, VEGFR1-3, and can inhibit angiogenesis and growth of SCLC and breast cancer cells in vitro and in vivo (208–211).