EPAS1 and malignant colon neoplasm: discovered that up-regulation of CEMIP is a critical regulator of colon cancer cells dissemination in a hypoxic microenvironment, hypoxia-inducible-factor-2α (HIF-2α) binds directly to the hypoxia response element within the CEMIP promoter region, resulting in increased CEMIP expression and enhanced cell migration (28).