discovered that up-regulation of CEMIP is a critical regulator of colon cancer cells dissemination in a hypoxic microenvironment, hypoxia-inducible-factor-2α (HIF-2α) binds directly to the hypoxia response element within the CEMIP promoter region, resulting in increased CEMIP expression and enhanced cell migration (28). This evidence concerns the gene EPAS1 and colonic neoplasm.