CEMIP has been linked to tumor progression and metastasis in different kinds of human cancers, including prostate carcinoma (9), colorectal tumors (10), hepatocellular carcinoma (11), breast carcinoma (12), gastric carcinoma (13) and oral squamous cell carcinoma (14), it acts as an oncogene, playing a vital role in the proliferation, migration and apoptosis in a variety of malignancies (15). This evidence concerns the gene CEMIP and hepatocellular carcinoma.