VDR and tuberculosis: However, the active form of 25(OH)D is mediated through the vitamin D receptor (VDR) to enhance macrophage activity and increase the production of cathelicidin, particularly the promotion of antimicrobial peptide LL-37 production, one of the defensins-antimicrobial peptides of the cathelicidin family involved in the TB destruction (17, 18, 48–54).