confirmed that the deletion of endothelial PHD2 promoted renal vascular remodeling and fibrosis by up-regulating Notch3/TGF-β1 signaling and increasing the coverage of pericytes (57).Studies have shown that HIF-1α can combine with HRE in the promoters of plasminogen activator inhibitor 1 (PAI-1) and tissue inhibitor of metalloproteinase (TIMPs), trans-activate the transcription of target genes, and inhibit ECM degradation and collagen decomposition, thus promoting renal fibrosis (58, 59). The gene discussed is SERPINE1; the disease is renal fibrosis.