We have further utilized the human protein atlas immunohistochemistry dataset (www.proteinatlas.org) to evaluate the expression of the DRRGs visually in cancerous and non-cancerous tissue, using this we examined the protein expression of the 2 main genes in SKCM. In tumor tissues, AK1 staining was lower, while TYMS staining was higher (Figures 3G–H). Here, AK1 is linked to neoplasm.