There have been many reports on the prognostic and biological importance of genetic changes linked to cancer such as PARP1 (12, 13), NRAS (14), absent in melanoma-1 (AIM1) (15), Methylguanine-DNA Methyltransferase (MGMT) (16) as well as KPNA2 (17) mutations in SKCM. The gene discussed is CRYBG1; the disease is cancer.