Reduced p-CREB expression exacerbates HFD-induced hepatic steatosis by downregulating PPARα (56), whereas activated p-CREB reduces PPAR-γ expression to regulate the hepatic DNL (57), which was confirmed by the downregulation of DNL-related ACC1 and FAS in GAS5 knockdown cells. This evidence concerns the gene FAS and Hepatic steatosis.