Subsequently, it was revealed that TCF7L2 overexpression has an opposite effect to CCDC183-AS1 knockdown on ECAR (Figure 8(a)), OCR (Figure 8(b)), glucose uptake (Figure 8(c)), lactate production (Figure 8(d)), and ATP level (Figure 8(e)) in UMUC3 and SW780 cells, confirming that CCDC183-AS1 modulates aerobic glycolysis in BC via upregulating TCF7L2. The gene discussed is PTGDR; the disease is breast cancer.