PRNP and prion disease: It is caused by the conversion of the normal form of prion protein (PrPC, prion‐related protein, in which C stands for the cellular form of the protein) with a primarily alpha‐helical structure into an abnormal form of the prion protein (PrPSc, proteinaceous infectious particle, in which Sc stands for scrapie, the prion disease of sheep and goats), which has a primarily beta‐pleated sheet structure, which then spreads and accumulates throughout the brain leading to spongiform neurodegeneration.1