Among the 69 NRGs, 18 DEGs were identified between normal and HCC samples as shown in the volcano plots and heatmap (Figures 2A, B; Supplementary Table S3), including 17 upregulated genes (TSC1, TRIM11, CASP8, TRAF2, USP22, SQSTM1, DNMT1, CDKN2A, HSPA4, PLK1, MYCN, TERT, SLC39A7, RNF31, HSP90AA1, LEF1, and TNFRSF21) and 1 downregulated gene (ID1). The gene discussed is CASP8; the disease is hepatocellular carcinoma.