It was recently suggested that CPAMD8 variants may be involved in the development of ASD (Cheong et al., 2016; Bonet-Fernandez et al., 2020; Ma et al., 2020), morgagnian cataract (Hollmann et al., 2017), and different subtypes of glaucoma, including POAG, PACG, and congenital glaucoma (Bonet-Fernandez et al., 2020; Siggs et al., 2020; Li X. et al., 2021b). The gene discussed is CPAMD8; the disease is open-angle glaucoma.