CPAMD8 and open-angle glaucoma: Variants of the CPAMD8 gene have been recently identified as causative factors for anterior segment dysgenesis (ASD) (Cheong et al., 2016; Bonet-Fernandez et al., 2020; Ma et al., 2020), morgagnian cataract (Hollmann et al., 2017), and different subtypes of glaucoma, including POAG, PACG, and congenital glaucoma (Bonet-Fernandez et al., 2020; Siggs et al., 2020; Wiggs, 2020; Li X. et al., 2021b), indicating that CPAMD8 variants may lead to primary and secondary glaucoma; different variants of the CPAMD8 gene may also determine the presentation and severity of ocular phenotypes.