Previous studies have found that the LDOC1 expression is reduced in certain malignancies, including colorectal cancer (Jiang et al., 2019), cervical cancer (Chen and Wang, 2019), pancreatic cancer (Nagasaki et al., 2003), prostate cancer (Salemi et al., 2016), and papillary thyroid carcinoma (Zhao et al., 2015). Here, LDOC1 is linked to Familial prostate cancer.