Among the 7 trios, we found several DEGs and DEMs have important implications for understanding the underlying mechanism of PCa, including hsa-miR-30b, hsa-miR-142-3p, ITGB8, and ELOVL7. miRNA hsa-miR-30b-5p was found to be related to 17 DEGs through 4 overlapped SNPs, and hsa-miR-30b-3p was correlated with 5 DEGs through 3 SNPs. This evidence concerns the gene ITGB8 and posterior cortical atrophy.