Microarray-based mRNA profiling revealed that in response to the knock-out of tafazzin, there are substantial (≥2fold) changes in transcript levels in rat C6 glioma cells (C6-TAZ vs. C6: 542 genes up-regulated, 484 down-regulated; a total of 1,026 genes differentially expressed). This evidence concerns the gene TAFAZZIN and central nervous system cancer.