As a member of the C-type lectin receptors (CLRs) family, CLEC4D has been identified as a pivotal “sensor” on myeloid cells in the host’s defense against fungal and bacterial infections (Kerscher et al., 2016; Wang et al., 2016; Huang et al., 2018; Xue et al., 2019). The gene discussed is CLEC4D; the disease is bacterial infectious disease.