In conventionally understood self-tolerance, host dendritic cells in the thymus display the self-antigens, causing either deletion of developing T cells that bind too-strongly to the antigen-MHC complex or conversion of such potentially-autoreactive cells into regulatory T cells (Treg) (Klein et al., 2014), that can down-regulate T cell responses to the antigens in the periphery, thus avoiding autoimmunity. Here, HLA-C is linked to Autoimmunity.