ADIPOQ and chronic kidney disease: However, in clinical investigations, as described by Lim et al. (2015), CKD patients had higher circulating adiponectin than their non-CKD counterparts, and after adjusting for confounders, participants with adiponectin levels in the 75th percentile had a 2.88-fold higher risk of CKD than those with levels in the 25 percentile.