Our analysis revealed a universal downregulation of STING signaling‐related gene expression in SCLC samples compared with normal lung tissues, including genes involved in dsDNA sensing (IFI16 and DDX60), STING pathway (STING), inflammasome (CASP1), pro‐inflammatory factors (NFKB1, CCL5, IL‐18), and type I IFN response (IFNAR1, IFIT1/2/3, IFITM2) (Figure 1B,C, Figure S1A,B). Here, IFIT1 is linked to small cell lung carcinoma.