The prevalence of TP53 and RB1 mutations showed no difference across STING subtypes, while NOTCH mutation was found more frequent in the STING‐low (7/23, 30.4%) and STING‐intermediate SCLCs (5/17, 29.4%) than in the STING‐high SCLCs (2/14, 14.3%) (Figure 4C), consistent with the observation at transcriptomic level which showed a low degree enrichment of NOTCH signaling in STING‐low SCLC (Figure 4A). The gene discussed is RB1; the disease is small cell lung carcinoma.