These results suggest that non‐malignant cells of the TME aid RMS cells to allow their proliferation through collagen remodeling, like previously reported in carcinomas.[7] Expression analysis of these proteins in primary and distinct metastatic RMS tumors at various sites will be of interest to determine whether these factors (i.e., DDR1, integrin β1, and matrix remodeling through MMPs) are predictive of preferential metastatic sites. The gene discussed is DDR1; the disease is carcinoma.