The results showed that the IC50 of Rh3 in colorectal cancer cells (HCT116) was 77.54 μg/mL, and in human normal colon epithelial cells (HCoEpiC) was 235.8 μg/mL (Figure 1A and Figure S1); thus, the SIRh3 was 3.04. Here, RTL6 is linked to colorectal cancer.