Moreover, Makhafola et al. (2020) concluded that C. orbiculata aqueous extract had an anti-proliferative effect in HCT116, KYSE70, and OE33 cancer cells, mediated by apoptosis induced by the alternative splicing of hnRNPA2B1 (an RNA-binding protein) and BCL2L1 (an important apoptosis-regulating gene) [13]. The gene discussed is BCL2L1; the disease is cancer.