A bioactive molecule isolated from Tripterygium wilfordii, namely celastrol, protected the cerebral region of the brain from an acute episode of cerebral ischemia by suppressing oxidative stress via phosphorylation of the c-Jun-N-terminal kinase (p-JNK) and NF-κB which aided in the reduction of ROS in the brain [92]. Here, MAPK8 is linked to brain ischemia.