CNR1 and obesity due to melanocortin 4 receptor deficiency: In a pharmacological context, the synthetic CBD derivatives have been developed to bind to a variety of receptors, including peroxisome proliferator-activated receptor-γ (PPAR-γ), cannabinoid receptor 1 (CB1) and cannabinoid receptor type-2 (CB2), leading to diverse pharmacological activities, such as anti-neuroinflammatory, antitumor, anti-obesity and cardioprotective effects [12,28].