Moreover, ALK gene activation appears to contribute to the initiation of carcinogenesis in a variety of human cancers such as anaplastic large cell lymphoma, lung cancer, inflammatory myofibroblastic tumors, and neuroblastoma, with the end result of fusion with additional oncogenes (NPM, EML4, TIM, etc.)and gene amplification, mutation, and protein overexpression [4]. The gene discussed is ALK; the disease is lung cancer.