Under normal conditions, RAGE inhibits PI3K/AKT and activates the AMPK/mTOR pathway to inhibit the regulatory molecule mTOR, promote autophagy, and complete the important turnover of intracellular substances, whereas overexpressed RAGE activates PI3K/AKT and inhibits the AMPK/mTOR pathway, inhibiting autophagy and promoting the growth and reproduction of cancer cells. Here, AGER is linked to cancer.