ROS1 and neoplasm: For example, Entrectinib inhibits the metastasis of non-small cell lung cancer by targeting ROS proto-oncogene 1(ROS1) and neurotrophic receptor tyrosine kinase (NTRK), ROS1 is a proto-oncogene highly expressed in various tumor cells, and ROS1 protein is a type I integral membrane protein with tyrosine kinase activity, and has achieved satisfactory clinical efficacy [53,54,55,56].