PDCD4 and gastric cancer: Jiayu Zhao et al. also discovered that HIF1α could bind to the promoter region of miR-17-5p to activate the transcription of pre-miR-17-5p and miR-17-5p, and miR-17-5p binds to the untranslated region of the gastric cancer suppressor gene programmed cell death 4 (PDCD4), the role of PDCD4 in gastric cancer mainly includes inhibition of cell proliferation, thus leading to the degradation of its mRNA.