Another important receptor expressed by astrocytes and playing an important role in neuroprotection is ChemR23/ERV1, expressed in the human hippocampus, which binds RvE1: animal studies demonstrated that peripheral administration of RvE1 in Alzheimer’s disease (AD), in combination with LXA4, reduced astrocyte activation [20]. The gene discussed is CMKLR1; the disease is early-onset autosomal dominant Alzheimer disease.