In ALS macrophages, aggregated superoxide dismutase-1 (SOD-1) stimulated the expression of inflammatory cytokines, including IL-1β, IL-6, and TNF-α; it was shown that RvD1 was able to inhibit macrophage IL-6 and TNF-α production, thus suppressing inflammation [104]. Here, TNF is linked to amyotrophic lateral sclerosis.