ANXA1 and Alzheimer disease: As previously mentioned, AnxA1 protects against BBB breakdown in AD: treatment with human recombinant ANXA1 (hrAnxA1) in the murine brain endothelial cell line bEnd.3 was able to rescue β-amyloid 1–42 -induced BBB disruption via inhibition of RhoA-ROCK signaling pathway [93].