Supporting the role of SPMs in PD, homozygous missense variants in the AnxA1 were recently suggested to cause parkinsonism by leading to extracellular SNCA accumulation, neuroinflammation, as well as defects in intracellular signaling pathways and synaptic plasticity; however, such mutations seem to be exceedingly rare, and pathogenicity could not be further explored [103]. Here, ANXA1 is linked to Parkinson disease.