Sun and Liu have reported that the 7α,25-DHC-GPR183 axis contributes to inflammation and various diseases, including cancer, autoimmune diseases, cardiovascular diseases, and neurodegenerative diseases, through the regulation of various physiological properties such as migration, activation, and function in B cells, T cells, dendritic cells, and immune cells [13]. The gene discussed is GPR183; the disease is autoimmune disease.