Unlike the simultaneous induction of CHOP and GRP78 by selenium (methylseleninic acid) alone in prostate cancer cells [59], a previous study reported the opposite regulation of CHOP and GRP78 by the combination of Se-Y and FO to induce apoptosis in A549 NSCLC cells via AMPK activation [16]. Here, HSPA5 is linked to Familial prostate cancer.