Unlike the simultaneous induction of CHOP and GRP78 by selenium (methylseleninic acid) alone in prostate cancer cells [59], a previous study reported the opposite regulation of CHOP and GRP78 by the combination of Se-Y and FO to induce apoptosis in A549 NSCLC cells via AMPK activation [16]. The gene discussed is HSPA5; the disease is non-small cell lung carcinoma.