The diagnostic criterion is weight loss of at least 5% in 12 months or less (or BMI < 20 kg/m2) in the presence of underlying disease, and is confirmed if three or more of the following five criteria are met: (1) decreased muscle strength; (2) fatigue; (3) anorexia (total calorie intake less than 20 kcal/kg body weight/day, less than 70% of normal food intake); (4) low fat-free mass index (lean body mass); and (5) abnormal biochemistry (Alb < 3.2 g/dL, Hb < 12.0 g/dL, C-reactive protein (CRP) > 0.5 mg/dL) [62]. Here, CRP is linked to Anorexia.