In agreement with this, the meta-analysis on nine RCTs found that consuming curcumin improves dyslipidemia, specifically reducing serum total cholesterol (TC) and LDL-C, ALT, AST, FPG, HOMA-IR, serum insulin, and WC, but not in serum TG, HDL-C, hemoglobin A1c (HbA1c), body weight, and BMI [81]. The gene discussed is INS; the disease is metabolic syndrome.