We have previously shown that consuming 1.5 g curcumin in addition to lifestyle intervention did not change hepatic steatosis and fibrosis, lipid profile, glucose, insulin resistance, ALT, anthropometric indices, [40] tumor necrosis-α (TNF-α), and nuclear factor-kappa B (NF-kB) activity [42]. This evidence concerns the gene NFKB1 and fatty liver disease.