In a systematic review, Western dietary patterns have interacted with T2DM-related PRS, fat and carbohydrate intake with IRS1_rs2943641, and physical activity with HNF1B, IRS1, PPARγ, ADRA2B, SLC2A2, and ABCC8 variants in European ethnicities [5,49]. Here, ADRA2B is linked to type 2 diabetes mellitus.