In conclusion, the participants with a High-PRS of the eight-SNP model that included rs7631705_UBE2E2, rs35612982_CDKAL1, rs61160304_PAX4, rs13266634_SLC30A8, rs7034200_GLIS3, rs10811661_CDKN2A/B, rs60808706_KCNQ1, and rs11651052_HNF1B showed a 10-fold elevation in T2DM risk compared to those with a Low-PRS. This evidence concerns the gene GLIS3 and type 2 diabetes mellitus.