Consistent with the present study results, Asians carrying CDKAL1_rs35612982, CDKN2A/B_rs10811661, and KCNQ1_rs60808706, which are mainly linked to β-cell mass, have an elevated susceptibility to T2DM, suggesting that T2DM in Asians may be closely related to reduced β-cell mass and function. This evidence concerns the gene KCNQ1 and type 2 diabetes mellitus.