SPP1 and ocular melanoma: Accordingly, as clearly shown in Figure 4, the increased mRNA levels (Figure 4A) and protein expression (Figure 4B,C) of ALP, OC, OPN, and COL1a1 induced by UF (10 μM; p < 0.05 vs. OM) were significantly inhibited by tamoxifen treatment (5 μM; p < 0.05 vs. OM).