Although the microsecretory beta-cellular activity of individual patients is not known, there is scientific evidence that this is present throughout the life of patients with DM1 [27], and that it is stimulated, in particular, by hyperglycemic meals; therefore it’s possible to hypothesize that the reduction of hypoglycemia events derive not only by a lower exogenous insulin units injection but also from a lower production of endogenous insulin as response to a high carb meal. Here, INS is linked to Hypoglycemia.