SIRT1 and diabetic cardiomyopathy: In this regard, it has been recently proven that tubular SIRT1 attenuates diabetic albuminuria by epigenetically suppressing claudin-1 overexpression in podocytes [83], whereas SIRT1 activators induce increased stress resistance in diabetic cardiomyopathy through the upregulation of the kinase ERK1/2 pathway and the sarcoplasmic reticulum Ca2+-ATPase SERCA2a [84].