SIRT1 plays a role in the modulation of the liver cholesterol efflux also through the LXR deacetylation and activation in the nucleus [92], but several other compounds have been described to attenuate NAFLD and lipid metabolism through the AMPK/SIRT1/PGC1-α pathway [124]. The gene discussed is SIRT1; the disease is metabolic dysfunction-associated steatotic liver disease.