In humans, the KD was initially used as a therapeutic option for its anticonvulsant effects in children with refractory epilepsy [32]; then, a very low carbohydrate ketogenic diet (VLCKD) was introduced for the treatment of obesity and its complications, such as insulin-resistance, type 2 diabetes [33], nonalcoholic fatty liver diseases (NAFLD) [34], and obstructive sleep apnea syndrome [35]. Here, INS is linked to metabolic dysfunction-associated steatotic liver disease.