A lower expression of SIRT1 may be responsible for the differentiation capacity of VAT-derived stem cells (ASC) in human obesity, fostering the expansion VAT [112], and visceral ASC isolated from subjects with obesity showed a reduction in the expression of SIRT1-6 when compared to both visceral ASC of normal weight subjects and ASC from subcutaneous adipose tissue [113]. Here, SIRT1 is linked to obesity due to melanocortin 4 receptor deficiency.