CASP3 and myelodysplastic syndrome: Cleaved caspase-3 levels in patients with low-risk MDS were significantly higher, followed by those in patients with high-risk MDS and ICUS (p = 0.004, ICUS vs. low-risk MDS, p = 0.009; low-risk MDS vs. high-risk MDS, p = 0.779; ICUS vs. high-risk MDS, p = 0.044) (Figure 3A).