Our previous study demonstrated that the TT genotype at rs10036748 in TNIP1 is associated with the PASI 75 and PASI 90 response to MTX in psoriasis patients, whichis related to MTX-inhibited NF-κB activation, and the variants of TNIP1 might correlate with the activation of NF-κB [16]. The gene discussed is TNIP1; the disease is psoriasis.