ACE2 and infection: Interestingly, the increase in sACE2 activity is associated with HF with reduced ejection fraction (HFrEF) but not with HF with preserved ejection fraction (HFpEF), suggesting (i) a rather complex role of HF in regulating ACE2-mediated infection by SARS-CoV-2 [188] and (ii) the potential of sACE2 activity to be used as a biomarker to distinguish between the two HF types.