This case series describes a heterozygous missense variant (c.77C>T, p.Thr26Met) in the PLCG2 gene that may cause a phenotypical overlap of PLAID and APLAID, although the pathogenicity is currently unclear. The gene discussed is PLCG2; the disease is autoinflammation-PLCG2-associated antibody deficiency-immune dysregulation.