PLCG2 and familial cold autoinflammatory syndrome 3: In 2012, Ombrello et al. described three families with variants in the PLCG2 gene affecting the autoinhibitory C-terminal Src-homology 2 (cSH2) domain, which was later proposed as PLCG2-associated antibody deficiency and immune dysregulation (PLAID) [3].