Several patients diagnosed as APLAID had the following clinical and laboratory characteristics: cutaneous findings (rashes, erythema, granulomas, cutis laxa and vesiculo-pustular lesions), eye inflammation, recurrent infections, abdominal pain and inflammatory bowel disease, musculoskeletal complaints, immunologic findings (reduced/normal immunoglobulins, reduced circulating class-switched CD27+ memory B-lymphocytes and decreased/normal NK cells) [5,8,9,12,14,15,16,17,18]. The gene discussed is CD27; the disease is Granuloma.