Background: Variants in the phospholipase C gamma 2 (PLCG2) gene can cause PLCG2-associated antibody deficiency and immune dysregulation (PLAID)/autoinflammation and PLCG2-associated antibody deficiency and immune dysregulation (APLAID) syndrome. The gene discussed is PLCG2; the disease is autoinflammation-PLCG2-associated antibody deficiency-immune dysregulation.