In our research, in addition to finding significantly decreased mean levels of HDL-C in adolescents with DS, we evaluated the concentrations of the main proteins characterizing the HDL fraction (ApoA-I and ApoA-II), and we observed significantly lower concentrations of ApoA-I, ApoA-II, and the ApoA-I/ApoA-II ratio in adolescents with DS. Here, APOA2 is linked to Dravet syndrome.